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नवीनतम संदेश 8
2022-06-08 05:09:03
https://t.me/USMLE_AMBOSS
298 views02:09
2022-06-07 20:17:01
Educational objective: The human leukocyte antigen (HLA) genes encode major histocompatibility complex (MHC) molecules that are key to activation of the immune system in response to foreign (non-self) antigens. All the HLA genes are clustered together, meaning that there is a low rate of crossover and that offspring essentially inherit 2 HLA haplotypes, one from each parent. Therefore, the probability that a sibling would be an identical HLA match is 1/4.
303 views17:17
2022-06-07 08:17:01
26 voters353 views05:17
2022-06-07 08:16:01
50-year-old previously healthy man is evaluated for progressive fatigue, weakness, and recurrent gingival bleeding. Laboratory studies reveal normocytic normochromic anemia, thrombocytopenia, and leukocytosis with circulating myeloblasts. Bone marrow biopsy establishes a diagnosis of acute myeloid leukemia. Induction chemotherapy followed by a11ogeneic hematopoietic cell transplantation (HCT) is planned. Molecular typing of human leukocyte antigen (HLA) -A, -B, -C, -DP, -DO, and -DR is performed. The patient's biological sister, with whom he shares both parents, is eligible for stem cell donation and undergoes HLA typing.
306 views05:16
2022-06-07 05:22:51
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https://t.me/USMLERECALLS2021/604
248 views02:22
2022-06-06 20:16:01
Educational objective: Many frequently encountered diseases (eg, hypertension, spinal bifida) display multifactorial inheritance, which involves the complex interaction of numerous genetic and environmental factors to determine phenotypic expression. Although the exact inheritance risk cannot be determined, the closer a relative is to the affected person, the more likely the relative is to develop the trait.
290 views17:16
2022-06-06 08:16:01
44 voters354 views05:16
2022-06-06 08:15:21
33-year-old woman, gravida 2 para 1, comes to the office for a prenatal visit at 20 weeks gestation. She feels well and reports experiencing fetal movements. The patient has no medical problems other than a history of cleft lip, which was repaired in childhood. Her husband is healthy, but her previous child was
born with spina bifida. She takes a daily prenatal vitamin. Physical examination is unremarkable and uterine size is in accordance with ultrasound dates. The patient is worried that the fetus may develop the same birth defect as her previous child.
344 views05:15
2022-06-06 02:55:04
https://t.me/studentdoctor
364 views23:55
2022-06-05 20:15:35
Educational objective: Autosomal recessive disorders affect 25°/o of offspring of asymptomatic heterozygous carrier parents. Classical galactosemia is the most common and severe galactosemic disorder and presents within days of birth with jaundice, vomiting, and hepatomegaly.
363 views17:15