A 50-year-old previously healthy man is evaluated for progress | USMLE Biochemistry Videos & Books

A 50-year-old previously healthy man is evaluated for progressive fatigue, weakness, and recurrent gingival bleeding. Laboratory studies reveal normocytic normochromic anemia, thrombocytopenia, and leukocytosis with circulating myeloblasts. Bone marrow biopsy establishes a diagnosis of acute myeloid leukemia. Induction chemotherapy followed by a11ogeneic hematopoietic cell transplantation (HCT) is planned. Molecular typing of human leukocyte antigen (HLA) -A, -B, -C, -DP, -DO, and -DR is performed. The patient's biological sister, with whom he shares both parents, is eligible for stem cell donation and undergoes HLA typing.