In an experiment, cultured fibroblasts are mechanically lysed, | USMLE Biochemistry Videos & Books

In an experiment, cultured fibroblasts are mechanically lysed, and the membrane lipids and cellular proteins are chemically removed to isolate nucleic acids. The cellular extract containing the purified nucleic acids is incubated along with short sequences of repeated deoxythymidine residues fixed to latex beads. The solution is washed several times to remove unbound molecules.